Unexpected Foci of Metastasis in a Patient with Thyroid and Breast Cancer: Which One’s Metastasis? Metastasis of Thyroid and Breast Cancer

Ayşegül Özdal; Tuğba  Uylar Seber; Semra  Aytürk Salt; Ersin Özaslan

doi:10.70087/rami.tui010105

Authors

Ayşegül Özdal, MD Department of Nuclear Medicine, Kayseri City Hospital, Kayseri, Türkiye Author https://orcid.org/0000-0002-7214-6151
Tugba Uylar Seber, MD Department of Radiology, Kayseri City Hospital, Kayseri, Türkiye Author https://orcid.org/0000-0002-5395-7004
Semra Ayturk Salt, MD Department of Endocrinology, Kayseri City Hospital, Kayseri, Türkiye Author https://orcid.org/0000-0002-1560-3459
Ersin Özaslan, Associate Prof. Dr. Department of Medical Oncology, Kayseri Acıbadem Hospital, Kayseri, Türkiye Author https://orcid.org/0000-0002-8333-676X

DOI:

https://doi.org/10.70087/rami.tui010105

Keywords:

thyroid cancer, breast cancer, metastasis, PET/CT

Abstract

Thyroid cancer, a common endocrine malignancy, has shown a notable rise in the occurrence in recent times and is commonly linked with breast cancer. While it generally presents a positive prognosis, the cancer’s aggressiveness and the stage at which it is diagnosed play crucial roles in determining the outcome. The objective of this case report is to emphasize the metastatic progression and uncommon metastatic locations in a patient diagnosed with thyroid cancer and concurrent unstaged breast cancer, who did not receive follow-up care for 20 years. The report also includes positron-emission tomography findings.

Downloads

Download data is not yet available.

References

Bolf EL, Sprague BL, Carr FE. A linkage between thyroid and breast cancer: a common etiology? Cancer Epidemiol Biomarkers Prev. 2019 Apr;28(4):6439. doi: 10.1158/1055-9965.EPI-18-0877.

Tanaka H, Tsukuma H, Koyama H, Kinoshita Y, Kinoshita N, Oshima A. Second primary cancers following breast cancer in the Japanese female population. Jpn J Cancer Res. 2001;92:1–8. doi: 10.1111/j.1349- 7006.2001.tb01040.x.

Hall LC, Salazar EP, Kane SR, Liu N. Effects of thyroid hormones on human breast cancer cell proliferation. J Steroid Biochem Mol Biol. 2008;109:57–66. doi: 10.1016/j.jsbmb.2007.12.008.

Zeng Q, Chen GG, Vlantis AC, van Hasselt CA. Oestrogen mediates the growth of human thyroid carcinoma cells via an oestrogen receptor- ERK pathway. Cell Prolif. 2007;40:921–35. doi: 10.1111/j.1365- 2184.2007.00471.x.

An JH, Hwangbo Y, Ahn HY, Keam B, Lee KE, Han W, et al. A possible association between thyroid cancer and breast cancer. Thyroid. 2015 Dec;25(12):1330-8. doi: 10.1089/thy.2014.0561.

Subramanian S, Goldstein DP, Parlea L, Thabane L, Ezzat S, Ibrahim-Zada I, et al. Second primary malignancy risk in thyroid cancer survivors: a systematic review and meta-analysis. Thyroid. 2007 Dec;17(12):1277-88. doi: 10.1089/thy.2007.0171.

Dong L, Lu J, Zhao B, Wang W, Zhao Y. Review of the possible association between thyroid and breast carcinoma. World journal of surgical oncology 2018;16:130. doi: 10.1186/s12957-018-1436-0.

Wapnir IL, van de Rijn M, Nowels K, Amenta PS, Walton K, Montgomery K, et al. Immunohistochemical profile of the sodium/ iodide symporter in thyroid, breast, and other carcinomas using high-density tissue microarrays and conventional sections. J Clin Endocrinol Metab. 2003;88:1880–8. doi: 10.1210/jc.2002-021544.

Nagamine Y, Suzuki J, Katakura R, Yoshimoto T, Matoba N, Takaya K. Skull metastasis of thyroid carcinoma.Study of 12 cases. J Neurosurg 1985;63:526-31. doi: 10.3171/jns.1985.63.4.0526.

Quinn TR, Duncan LM, Zembowicz A, Faquin WC. Cutaneous metastases of follicular thyroid carcinoma. Am J Dermatopathol 2005;27:306-12. doi: 10.1097/01.dad.0000164606.33779.6f.